Relevance of COX‐2 gene expression in dementia with lewy bodies associated with Alzheimer pathology
Identifieur interne : 002651 ( Main/Exploration ); précédent : 002650; suivant : 002652Relevance of COX‐2 gene expression in dementia with lewy bodies associated with Alzheimer pathology
Auteurs : Marisa Salda A [Espagne] ; Laura Pujols [Espagne] ; Joaquim Mullol [Espagne] ; Jordi Roca-Ferrer [Espagne] ; Adriana Cardozo [Espagne] ; Esther Aguilar [Espagne] ; Mercè Bonastre [Espagne] ; Concepci Marin [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-30.
English descriptors
- KwdEn :
- Adult, Aged, Alzheimer Disease (genetics), Alzheimer Disease (pathology), Cyclooxygenase 2 (genetics), Dementia (genetics), Dementia (pathology), Female, Frontal Lobe (enzymology), Frontal Lobe (pathology), Gene Expression Regulation, Humans, Lewy Bodies (genetics), Male, Middle Aged, RNA, Messenger (genetics), Reverse Transcriptase Polymerase Chain Reaction, Substantia Nigra (enzymology), Substantia Nigra (pathology), cyclooxygenase‐2, dementia with Lewy bodies, neurodegeneration, neuroinflammation, parkinsonism, tyrosine hydroxylase.
- MESH :
- chemical , genetics : Cyclooxygenase 2, RNA, Messenger.
- enzymology : Frontal Lobe, Substantia Nigra.
- genetics : Alzheimer Disease, Dementia, Lewy Bodies.
- pathology : Alzheimer Disease, Dementia, Frontal Lobe, Substantia Nigra.
- Adult, Aged, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
The aim of the present study was to investigate whether cyclooxygenase‐2 (COX‐2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX‐2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real‐time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX‐2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX‐2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX‐2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21860
Affiliations:
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xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Rinologia, Servei d'Otorinolaringologia, Hospital Clínic, Immunoal.lèrgia Respiratòria Clínica i Experimental, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Respiratorias (CIBERes)</wicri:regionArea></affiliation></author><author><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurological Tissue Bank, University of Barcelona/Hospital Clínic, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Aguilar, Esther" sort="Aguilar, 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level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-30">2008-04-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="804">804</biblScope><biblScope unit="page" to="810">810</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">31D5A051890D94A4C377EC86833185CEC98A0ACE</idno><idno type="DOI">10.1002/mds.21860</idno><idno type="ArticleID">MDS21860</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alzheimer Disease (genetics)</term><term>Alzheimer Disease (pathology)</term><term>Cyclooxygenase 2 (genetics)</term><term>Dementia (genetics)</term><term>Dementia (pathology)</term><term>Female</term><term>Frontal Lobe (enzymology)</term><term>Frontal Lobe (pathology)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Lewy Bodies (genetics)</term><term>Male</term><term>Middle Aged</term><term>RNA, Messenger (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Substantia Nigra (enzymology)</term><term>Substantia Nigra (pathology)</term><term>cyclooxygenase‐2</term><term>dementia with Lewy bodies</term><term>neurodegeneration</term><term>neuroinflammation</term><term>parkinsonism</term><term>tyrosine hydroxylase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclooxygenase 2</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Frontal Lobe</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Lewy Bodies</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Frontal Lobe</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the present study was to investigate whether cyclooxygenase‐2 (COX‐2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX‐2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real‐time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX‐2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX‐2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX‐2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Salda A, Marisa" sort="Salda A, Marisa" uniqKey="Salda A M" first="Marisa" last="Salda A">Marisa Salda A</name></noRegion><name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name><name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name><name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name><name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name><name sortKey="Joaquim Mullol" sort="Joaquim Mullol" uniqKey="Joaquim Mullol" last="Joaquim Mullol">Joaquim Mullol</name><name sortKey="Joaquim Mullol" sort="Joaquim Mullol" uniqKey="Joaquim Mullol" last="Joaquim Mullol">Joaquim Mullol</name><name sortKey="Marin, Concepci" sort="Marin, Concepci" uniqKey="Marin C" first="Concepci" last="Marin">Concepci Marin</name><name sortKey="Marin, Concepci" sort="Marin, Concepci" uniqKey="Marin C" first="Concepci" last="Marin">Concepci Marin</name><name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name><name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name><name sortKey="Roca Errer, Jordi" sort="Roca Errer, Jordi" uniqKey="Roca Errer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name><name sortKey="Roca Errer, Jordi" sort="Roca Errer, Jordi" uniqKey="Roca Errer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name><name sortKey="Salda A, Marisa" sort="Salda A, Marisa" uniqKey="Salda A M" first="Marisa" last="Salda A">Marisa Salda A</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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